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These include the clearance of potentially detrimental metabolites and protein fragments, such as soluble A, from the brain [14], influencing tau protein dynamics [8], supporting the function of the blood-brain barrier (BBB) [15], maintaining synaptic integrity [16], consolidating memory [17], modulating glial activation [18], and regulating neuroinflammation [19]

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doi: 10.1074/jbc.RA119.011881 111 MetlakuntaAHuangWStefanovic-RacicMDedousisNSipulaIO'DohertyRM

Taken together, these studies show that maintaining the integrity of the lysosomal structure and function or inhibiting the activity of cathepsin B, may be promising therapeutic targets for acute pancreatitis

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