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(1973) Studies on S-adenosylhomocysteine inhibition of histamine transmethylation in brain, J

Coates RJ

Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy

Compared to 108 control subjects without evidence of dementia, subjects with dementia of Alzheimer's type and confirmed Alzheimer's disease had higher blood levels of homocysteine and lower blood levels of folate and vitamin B 12

Normal methylation supports cardiovascular health, DNA synthesis, and the production of SAM-e (S-adenosylmethionine), a compound involved in mood regulation and cellular repair.*

Scientists are continuing to investigate its pharmacokinetics, metabolic pathways, long-term safety profile, and regulatory toxicology, but translating findings from laboratory and animal models into human applications is a significant challenge