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Moreover, multiple studies have shown that the plasma levels of 4-HNE and MDA are significantly elevated in patients with renal failure and are directly associated with the degree of renal damage (52)

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The 2022 AAP guidelines provide updated risk-stratified Bhutani nomogram thresholds for initiating and escalating phototherapy based on gestational age, postnatal age (hours), and neurotoxicity risk factors (Kemper et al., Pediatrics 2022)

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