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Berti, M

152 Dysregulation of Wnt/-catenin signalling is often caused by mutations of various components in the pathway, particularly mutations or silencing of the Wnt tumour suppressor, which occurs frequently in various cancer types, such as adenomatous polyposis coli (APC) mutations, 193 Axin1/2 mutations, 194,195 GSK3 deletions, 196 inactivation mutations of E3 ubiquitin ligase RNF43, 196 and Znrf3

Rajamani K, Colman PG, Li LP, Best JD, Voysey M, DEmden MC, Laakso M, Baker JR, Keech AC, FIELD study investigators

International Agency for Research on Cancer (IARC) International Agency for Research on Cancer (IARC) is part of the World Health Organization (WHO)

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Conflict of interest The author(s) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest