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While B12 injections are generally safe, some individuals may experience minor side effects, such as: Pain or swelling at the injection site Mild diarrhea Dizziness or headache Rare allergic reactions, including rash or difficulty breathing Severe side effects are uncommon

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Most of what we know is preclinical, and real-world human trials are not yet strong

In April 2026 the medicines regulator opened an investigation into peptide clinics making health claims about products they cannot legally sell as medicines [12]

Possible side effects include headaches, nausea, skin redness, or mild dizziness