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However, the complex pathogenesis of RA is incompletely understood

In addition to these reported modes of action, bidirectional communication between the brain and gut and the upregulation of low-molecular-weight metabolites have been reported (Ng et al., 2014)

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Through these mechanisms, SIRT1 emerges as critical factor in the pathophysiology of CVDs, including heart failure, atherosclerosis, hypertension, and myocardial infarction