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Disruption of central nervous system barriers in multiple sclerosis

Chelation therapy removes harmful metals from the body

350 Mitochondrial dysfunction in Schwann cells triggers alterations in lipid metabolism, leading to myelin sheath dysfunction and accumulation of toxic lipid intermediates, which cause axonal degeneration and neuropathy

In addition to axon length, diseased CSMN treated with NMN also displayed improved branching and arborization especially within the 50200 m radius, as revealed by Sholl analyses (Fig