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prednisone may be preferred in a patient with reduced renal function, especially eGFR 0.5 0.8 mg/kg are generally fatal, and deaths have occurred with even lower doses

Targeting the tumor vasculature: from vascular destruction to vascular normalization The original concept of anti-angiogenic therapy simply focused on inhibition of new vessel formation and the destruction of established vessels to starve tumor cells to death

In this study we report on an oxaliplatin-based platinum(IV) prodrug, which releases L -buthionine- S , R -sulfoximine (BSO), an inhibitor of glutamate-cysteine ligase, the rate-limiting enzyme in GSH biosynthesis

The released MeCD depletes membrane cholesterol, suppressing tumour cell softening and thereby blocking biomechanics-mediated immune inhibitory pathways, which enhances CTL-mediated killing of cancer cells by diABZIs

10.1111/j.1365-2958.2009.06597.x Mol