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5.1 Overview of ferroptosis Ferroptosis is an iron-dependent form of cell death driven by the accumulation of lipid peroxides ( Ferroptosis depends on iron-dependent lipid peroxidation, with its key signaling regulation falling into three broad categories: iron metabolism, glutathione metabolism, and lipid metabolism ( is an essential amino acid antiporter composed of two subunits, SLC7A11 and SLC3A2

However, the oversimplified linear paradigm that equates neurodegeneration with harm fails to explain the complex phenomena observed in this field

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It can be fused to either the N -terminus or C -terminus of a protein

Sikiri P, Petek M, Rucman R, Seiwerth S, Grabarevi Z, Rotkvi I, et al