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This bidirectional regulatory process involves multiple interrelated mechanisms, including dysregulation of local prolactin synthesis and secretion (e.g., originating from adipose tissue or other extrapituitary tissues), alterations in prolactin metabolism and clearance processes, and a persistent chronic low-grade inflammatory state ( Figure 2 )

Rimmer, G

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However, LC-FFA-induced mitochondrial remodeling, swelling and disruption to networks has, to the best of our knowledge, been shown almost exclusively in rodent -cells