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The Ile105Val polymorphism of the GSTP1 gene, encoding glutathione S -transferase P1, has been associated with a decreased risk of oxaliplatin-related CIPN

Fructose in food is a big reason for this imbalance

Similarly, ROS also enhance inflammation through NF-B pathway activation, leading to IB degradation, NF-B nuclear translocation, and transcriptional upregulation of inflammatory mediators [93, 94]

Additional biomarkers like neuroinflammatory markers (e.g., TNF, IL6) and genetic variants (e.g., LRRK2, GBA mutations) contribute to early risk stratification [64, 79, 173, 250]

[4] Stay hydrated and maintain a balanced diet : Try to drink plenty of water and maintain a nutrient-rich diet, as it supports healthy circulation and nourishment to the hair follicles

Glutamate excitotoxicity can lead to increased production of neuronal nitrogen oxide synthase (nNOS) which in turn can lead to higher production of reactive nitrogen species, damage to cellular components, and ultimately, cell death (Sullivan and Brown, 2005), and this is thought to be mediated by the oxidative stress triggered by excitotoxicity (Nguyen et al., 2011)