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This mechanism of metabolic crosstalk has deepened our understanding of the role of acylcarnitine as a metabolic messenger for intertissue communication and revealed its critical role in coordinating energy metabolism

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In adipose tissue, the uptake of SUA by adipocytes can disrupt insulin signaling, inhibit the activity of peroxisome proliferator-activated receptor (PPAR ), and lead to disorders in preadipocyte differentiation disorder, mature adipocyte, as well as hypertrophy and dysfunction in mature adipocytes

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N., Donnelly, P

Growth hormone secretagogue (GHS) and GHS receptor (GHS-R) function in human adipose tissue