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The FLS is an important class of cells and chief contributor of the hyperplasia of synovium, which is involved in the pathogenesis and progression of RA by regulating the secretion of inflammatory mediators like TNF-, IL-6, IL-1, chemo-attractant protein-1 (MCP-1), IL-17, monocytes, cyclooxygenase-2 (COX-2), and IL-1-inducible nitric oxide synthase (iNOS)

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