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IL-6 and TNF- are representative pro-inflammatory cytokines that amplify epithelial damage, promote immune cell recruitment, and drive the progression of radiation-induced proctitis

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NPs are ubiquitously found in numerous edibles, nutritional additions, and spritzers utilized for veneering, disinfecting, and saturating (8284)

Additionally, they differ in their mechanisms of executing cell death: necroptosis typically serves as an alternative pathway when apoptosis is inhibited, mediated by the activation of the pseudokinase MLKL, hereas ferroptosis is triggered by the accumulation of iron-dependent lipid peroxides [121]

Scientists have tried adding a variety of lyoprotectants, such as sucrose, trehalose, mannitol, and other analogous compounds, to minimize lyophilization destruction and preserve the quality and dimensions of EXOs