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extracellular matrix components including, but not limited to, collagen III the evaluations included the assessment of the subject's face by trained investigators for fine lines and coarse wrinkles in the pen-orbital area, fine lines and coarse wrinkles in the pen-oral area, tactile roughness, mottled hyperpigmentation, redness and telangiectasia, skin pores and pore size, skin tone, and for global skin damage using visual severity scores

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