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doi:10.1172/JCI59755

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It is interesting to note that although KO mice for GH receptor/GH binding protein and for GH-releasing hormone showed an extended longevity (250, 251), this effect was not observed when using targeted deletion of the GH receptor in the liver, muscle, or adipose tissue (Table 3) (252)

For those with a ubiquinol deficiency, supplementing with CoQ10 may provide significant health benefits.*

Future agro-biotechnological approaches will therefore need to combine spatiotemporal control of gene expression with agronomic and microbial strategies to increase spermidine where and when it is most beneficial, without negative pleiotropic effects