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These include approved prescription weight-loss medications based on synthetic peptides that mimic natural hormones, such as semaglutide and tirzepatide, found in weight loss drugs such as Wegovy and Mounjaro respectively

Microglia control vascular architecture via a TGF1 dependent paracrine mechanism linked to tissue mechanics

Both medicines remain in active clinical development, with phase 2 and phase 3 trials ongoing

12 301302 (Oxford University Press, (2011)