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& Gottardi, C

Quantitative assays are also recommended for those with abnormal or equivocal qualitative assay results so as to verify the diagnosis

55% of recruited participants were women, with no statistically significant differences between the MOD, SEV or CTRL groups in these aspects

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Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )