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doi: 10.1111/pce.13021 123 TownsleyB

Known as the bloodbrain barrier (BBB), this extraordinary and intricate biological construct stands as a highly selective and protective threshold that demarcates the juncture between the periphery and CNS (Figure 1)

Pain relief following application of the hydrogel lasted at least 24 h, with low plasma and tissue concentrations of ropivacaine, indicating minimum systemic distribution

International Journal of Clinical Pharmacology and Therapeutics, 46 (11), 564570

10.1167/iovs.66.3.25 129

Furthermore, this focused drug administration should enhance therapeutic bioavailability and diminish side effects, thereby revolutionizing the management of PD (22, 23)