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It contributes to the exposure of senescent-specific neo-antigens, which subsequently bind autologous immunoglobulin G (IgG), triggering the removal of erythrocytes from circulation

Investigations Elevations of alkaline phosphatase and/or gamma glutamyltranspeptidase have been correlated with cholestasis and liver involvement

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Perilli and Sabatini 2010

For PROTACs specifically, additional challenges include resistance mechanisms, limited tissue-specificity of available E3 ligases, poor oral bioavailability, and risks of off-target protein degradation in non-target tissues

What happens in cells Inside cells, glutathione reduces oxidative stress and oxidative damage, including stress induced by hard training