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However, these models have not successfully recapitulated CD until recently, when Abadie and colleagues modified the DQ8-D d -IL-15tg model to overexpress IL-15 in intestinal epithelial cells under the villin promoter, resulting in the DQ8-D d -villin-IL-15tg model (Abadie et al, 2022

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All laboratory values were within the reference range or were judged by the investigator not to be clinically relevant