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In order to assess the study level risk of bias, we used the modified Cochrane risk of bias tool [22], and we evaluated the certainty of the evidence using the GRADE [20]

As a result, it inhibited SREBP-1c expression, reduced lipid accumulation, and affected ABCA1 expression

Dopaminergic Agents Drugs that increase dopamine signaling, including pramipexole (Mirapex), ropinirole (Requip), and transdermal rotigotine (Neupro), as well as levodopa plus carbidopa (Sinemet), were historically recommended as first-line therapies for RLS and have well-established efficacy (Dopp 2026

Supplement alternatives to ALA If youre exploring options beyond alpha-lipoic acid for nerve health or oxidative stress, two of the most studied and promising alternatives are vitamin B12 and acetyl-L-carnitine (ALCAR).56 Each plays a unique role in nerve protection and repair, particularly in the context of diabetic neuropathy

Kumagai, H., Yoshikawa, T., Zempo-Miyaki, A., Myoenzono, K., Tsujimoto, T., Tanaka, K., & Maeda, S

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