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doi: 10.1038/srep35393 58 KongL.WangM.BiD

Therefore, this example underscores that merely increasing activation (e.g., via AS3MT) is insufficient

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Once c-MET binds with HGF, it can mediate various downstream signaling molecules such as the MAPK family, JAK/STAT3, and PI3K/AKT, interacting with other ligand-receptor downstream pathways (Zhao et al., 2022)

Nevertheless, the distinct aggregation behaviors underscore the multifaceted nature of the pathology and present formidable challenges for therapeutic development