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Very encouraging results have been obtained for transfusion-dependent beta-thalassemia major patients, and were presented by the corresponding clinical investigators at the annual meeting of the American Society of Hematology (ASH) in December 2014 [184], [185]

Mechanistically, BPC-157 appears to modulate angiogenesis, upregulate growth factors such as VEGF and FGF, and influence nitric oxide pathways, contributing to enhanced vascularization, tissue repair, and anti-inflammatory effects

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Knowledge Gaps and Open Questions Several questions remain underdetermined in the peer-reviewed record

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