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PMID: 23387732

For example, if the risk of anesthesia is high (due to severe illness or an underlying heart condition), there is a lack of access to facilities offering endoscopy, or the owner cannot afford the procedure

, 11 , 403-414, Heller, R

Furthermore, the positively charged polycationic systems interact readily with the negatively charged plasma proteins when administered intravenously and opsonization occurs following binding to blood proteins which target them to be cleared by the reticulo-endothelial system (RES)