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They confirm cold chain integrity before opening the package, they use fresh sterile syringes for every draw, and they refrigerate within 10 minutes of reconstitution every single time

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In addition, future research could draw inspiration from anecdotal evidence that opioids can induce pain asymbolia, i.e., intact detection of pain but without the affective-motivational component (Berthier, Starkstein, & Leiguarda, 1988)