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Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12

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My personal thought is that it is always preferable to use naturally occurring sources of vitamins/nutrients whenever possible and to avoid man-made synthetic versions