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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)

Our cases report confirmed findings from studies that link HLA-B*58:01 and allopurinol-induced SJS/TEN conducted in other Asian countries, including Thailand and Vietnam ( HLA-B*58:01 in Javanese ethnics is around 6%, which is comparable to other Southeast Asian populations ( HLA-B*58:01 allele is quite frequent among the study participants ( Our study supports findings from other studies that HLA-B*58:01 can potentially be used as a pharmacogenetic marker for allopurinol-induced SCARs ( HLA-B*58:01 among population in the region ( HLA-B*58:01 and SCARs and provide evidence for policymaking on genetic screening test in Indonesia is warranted

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doi: 10.1111/jpn.13725 109 WilliamsERumseyRPowersH

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doi: 10.1001/jamaoncol.2024.1930 115 OverbeekKAGogginsMGDboukMLevinkIJMKoopmannBDMChuidianMet al