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This will keep the needle from bending as you insert it into the rubber stopper

3) could possibly lead to toxicity in the kidney, resulting in damage of the tubules, interstitium, glomerulus, or renal microvasculature, and consequently resulting in various clinical manifestations (Table 1) (Mayszko et al

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The question is never whether side effects exist, but whether the benefits justify them and whether those side effects are manageable in practice