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The combination of incretin and glucagon signaling axes in a single scaffold offers researchers a tool to interrogate how coordinated multi-receptor activation influences downstream metabolic signaling networks

Acknowledgments The authors gratefully acknowledge Khalifa Center for Genetic Engineering and Biotechnology-UAEU (Grant number: 12R255), and the UAEU program of Advanced Research (Grant number: 12S169) for supporting this work

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These benefits occurred long before the patients demonstrated significant weight loss

The methylation rate of the cells is severely diminished to about ten to twenty percent of normal