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10.1089/ars.2010.3581 76

Chapter 19

This induction represents an adaptive response to lysosomal stress associated with obesity to inhibit inflammation in adipose tissue and insulin resistance, irrespective of any modulation in food intake [77]

in contrast, when these mice are fed a high-Mn diet containing 2400 ppm Mn, they present increased Mn levels in the serum, brain, and pancreas, but not in the liver 49 , indicating that SLC39A14 mediates the transport of Mn from the circulation to the liver