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In PIONEERI and PIONEERII clinical trials for Adalimumab, 41.8% and 58.9% of HS patients reached, respectively, a HiSCR (Hidradenitis Suppurativa Clinical Response), defined as a 50% reduction in the total abscess and inflammatory nodule (AN) count [226]

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Effets sur les animaux de laboratoire et les systmes d'preuve in vitro 7.1 Exposition unique Les valeurs de la DL 50 pour le rat et la souris et de la CL 50 pour le rat et le hamster dor montrent que la toxicit aigu de l'actaldhyde est faible

Because it is small and uncharged, it readily passes through membranes into cells (Lynch and Fridovich, 1978