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Signal Detection Signal detection involves analyzing safety data to identify previously unknown or changing patterns of adverse drug reactions

421,458 Alterations in the balance of descending modulatory pathways are hypothesized to sustain chronic pain states, with a reduction in inhibitory control and an increase in facilitatory activity within both the brain and spinal cord

Feb 2017;65(2):148-153

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Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid