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Our biological individuality means that a patients dose and ratio must be titrated according to affect

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Next-generation agents with renal-specific targeting are emerging: bispecific antibodies reduce extrarenal toxicity in preclinical models by selectively modulating macrophages, while gene-edited chimeric antigen receptor regulatory T cells (CAR-Tregs) restore immune tolerance by homing to injured glomeruli via integrin 81 ligands

This biphasic response curve, where both microgram and nanogram doses work equally well, is unusual and mechanistically unclear

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