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In contrast to mutations in SLC39A8, mutations in the Mn importer SLC39A14 lead to the accumulation of Mn in the brain and in various other extrahepatic tissues, which is characterized by neurological deficits, motor dysfunction, and gastrointestinal damage 48,49,50,51

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Another characteristic of PD is oxidative DNA damage, which triggers PARP activation, leading to the depletion of NAD + levels 40,279,282,283,284

doi:10.1006/abbi.1996.9774 Zientek MA, Youdim K (2015) Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes