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Redox regulation of the afferent arteriole and tubuloglomerular feedback

Despite her electronic health record indicating only social drinking and a normal physical examination, her recent legal consequence suggests problematic drinking behavior that should be explored using open-ended, non-judgmental inquiry, making the most appropriate initial response "Do you have any concerns about your alcohol use?" When a patient discloses an adverse event related to substance use, such as a legal citation, the physician must assess for problematic drinking

PLos One (2012) 7:19

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Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide

In severe cases, a dose of 600 to 1200mg may be administered once daily