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This delay affects the capability of facing systemic infections and increases the susceptibility to allergies

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, which in turn activate downstream inflammatory signaling like TLRs signaling, thereby triggering robust inflammatory responses (Seo et al., 2021)

460 Astrocytes may contribute to the pathophysiology of schizophrenia through an increased production of NMDA receptor blocker kynurenic acid, which may also link risk of schizophrenia with infection as described in the previous chapter