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In lung squamous cell carcinoma (LUSC), patient survival was not associated with the total number of CAFs, but with their spatial closeness to tumor cells [303]

10.1111/cns.14604 124 WangX.HuM.ChenJ.LouX.ZhangH.LiM.et al (2024)

However, recent studies demonstrated that AKR1B and AKR1C3 are highly expressed in many human cancers including prostate, neuroblastoma and lung and they are crucial to regulate cell differentiation and cancer cell proliferation as well as to mediate drug resistance (3237)