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The process of pyroptosis mainly involves the caspase-1-dependent pathway (classical pathway) and the caspase-1-independent pathway (non-classical pathway), and is closely related to the secretion and activation of the pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, which play an important role in inflammatory response and immune defense through the release of inflammatory mediators and the recruitment of immune cells (103105)

Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury

Int J Mol Sci 22(13):6923 Matthews HK, Bertoli C, De Bruin RA (2022) Cell cycle control in cancer

The review also identified a scarcity of longitudinal incidence data, with only one relevant study reporting a baseline incidence of approximately 8% among individuals aged 4892 years

The rationale is straightforward: these peptides work through complementary mechanisms, and together they may address more aspects of disc healing than either can alone