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of USSN 09/790,321, filed February 21, 2001 (entitled Capillary Array-Based Enzyme Screening)

This bridge appears to further stabilize the molecule and may increase its resistance against degradation in various environments, including stomach acid

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It is well investigated that BCAAs have a significant positive correlation with blood glucose, blood lipids, and the insulin resistance index, and can be used as potential biomarkers for the early prediction of diabetes [275]

Therefore, metabolic vulnerabilities are attacked using the synthetic lethality approach in ovarian cancer cells overexpressing xCT, rather than directly inhibiting xCT or GPX4

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