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AIP-2 was found to be one of the most abundant proteins in the hookworm ES proteome (114), and it was recently demonstrated that intranasal delivery of recombinant AIP-2 protein could suppress airway inflammation in a mouse model of asthma and suppress antigen-specific T cell proliferation in human subjects allergic to house dust mite using in vitro stimulation (156)

Future studies are likely to explore additional combination therapies, particularly those involving drugs with distinct mechanisms of action, such as pairing iron chelators with antioxidants or mitochondrial protectants (64)

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Mitochondrial -synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

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