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From the several sites that can generate superoxide in the mitochondrial matrix, only the superoxide produced at complex III appears to be released both into the matrix and the IMS (Quinlan et al., 2013)

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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinsons disease

When ROS levels increase or the cellular capacity to mitigate oxidative stress diminishes, the frequency of oxidative assaults on cells rises, ultimately resulting in heightened oxidative stress

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