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However, their use is associated with several side effects, such as disruption of hormonal balance , or a negative impact on the liver or cardiovascular system

Over-the-counter hydrocortisone can also reduce inflammation

Whether used alone or in combination with other peptides, Pentadeca Arginate is poised to become an essential component of innovative treatment protocols aimed at optimizing patient health and recovery

Goldman adds

While one trial did show VAX-D to be more effective than TENS, concerns about study design, limited generalizability, and safety risks have kept it from being widely accepted as a standard treatment (Aetna Clinical Policy Bulletins, 2025)

This is sound reasoning, and some have suggested that the term CAM should be replaced by the term biomedical to reflect the underlying goal of treating abnormal biomedical function, as with pharmaceutical drugs