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People with poor gaba activity may tend towards anxiety and panic to the point that they have an ongoing sense of dread

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dementia.9,14,15 Chronic heavy alcohol con- Dementia is common among older people sumption can also produce dementia large 10% of people over the age of 65 have demen- amounts of alcohol have a direct toxic effect tia and over 30% of those over 85 are affected

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(2020) discovered that rats treated with LPS exhibited significant increases in the phosphorylation levels of NF-B p65 and IBa, as well as MLCK and MLC, leading to a decrease in ZO-1 and occludin expression which compromised intestinal epithelial cell integrity and increased permeability