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Research on ferroptosis began with the discovery of the small-molecule erastin

J Biol Chem 274:2159821602 Burk RF (2001) Selenium: recent clinical advances

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Similarly, NACs antioxidant action and ability to modulate kinin B1 receptor expression may alleviate sensory polyneuropathy, hypertension and metabolic parameters associated with diabetes and insulin resistance, as diabetes mellitus is associated with depletion of cellular antioxidants and an increase in reactive oxygen species levels with resultant protein damage [14]

Plant Physiology 94, 1012 1018

Compared with females, males exhibit a higher incidence of PD [11]