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Basal DA efflux in the striatum was reported to be similar in D 2 / and D 2 +/+ mice [30], although an increase in DA metabolites was found by others [31]

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Furthermore, Guilin Chang et al.s study, published in 2019, included only nine studies on the elderly population and did not consider young and middle-aged IS patients ( 2 Materials and methods The study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (Moher et al., 2009)

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