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Unlike other organs, the energy metabolism of the brain involves complex cellular interactions

doi: 10.1038/nm1477 26 DengR.LeeA.P.MaiaM.LimJ.J.BurgessT.HornP.et al

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J Neural Transm (Vienna) 104:661677 Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, Takanashi J, Matsuda T, Shimizu E, Ikehira H, Iyo M, Hashimoto K (2008) Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study

These combined challenges highlight the complexity of targeting cancer metabolism and suggest that a combined treatment strategy targeting multiple pathways or molecules may be more effective, despite presenting considerable challenges

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