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Energy from starting substrates such as glycogen, lipids, and proteins are gradually extracted by the complex series of enzymes in the cellular cytoplasm and mitochondria, resulting in metabolites, mainly CO 2 and H 2 O

The Fukuda criteria were established in 1991 and provided a comprehensive definition of chronic fatigue syndrome (CFS)

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Annu Rev Physiol 70:431457 Thornton DJ, Rousseau K, McGuckin MA (2008) Structure and function of the polymeric mucins in airways mucus

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Moreover, treatment with 1400W, an inhibitor of iNOS, prevents endoplasmic reticulum stress and apoptosis induced by mitochondrial dysfunction (Shen, 2010)