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On the one hand, CHAC1 demonstrates tumor-suppressive properties by promoting apoptosis and ferroptosis in response to cellular stress, such as oxidative stress and ER stress

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doi: 10.1016/j.jep.2023.116574 55

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Resende, R

By the mid-2000s, the obesity pharmacotherapy field expected at least 5% placebo-subtracted weight loss for regulatory consideration, a threshold later codified in FDA's 2007 guidance for industry on developing obesity drugs