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Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock

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For this purpose, activation of adaptive stress responses was investigated for DNA damage (p21), oxidative stress (SRXN1), inflammation (ICAMI), and ER stress (CHOP) using a HepG2-based GFP-reporter assay (Wink et al., 2014, 2017)

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Although other types necrotic cell death such as pyroptosis and necroptosis are mediated by the formation of membrane pore, ferroptosis is believed to result from the accumulation of unrepaired cell damage [70]

This last point is speculative